Bilosomes as a Potential Carrier to Enhance Cognitive Effects of Bacopa monnieri Extract on Oral Administration

Abstract The Indian system of medicine, Ayurveda employs Bacopa monnieri extract (BME) for memory enhancement. This study attempts to prepare and test a more potent formulation by incorporating BME in nanovesicles. BME-loaded liposomes bilosomes (bile salt-stabilized liposomes) were formulated using soy phosphatidylcholine. Liposomes had homogeneous size distribution an average 285.7 nm 84 nm, respectively, with satisfactory zeta potential. Spherical multilamellar unilamellar observed under transmission electron microscope (TEM), entrapment efficiency 85% 45%, respectively. During 72 h interval, released 78% 65% the loaded BME, exhibiting biphasic release, following Higuchi model diffusion. Both stable simulated gastric intestinal fluids. When tested on dementia-induced Swiss albino mouse models Y-maze apparatus, bilosome-treated group showed significant cognition enhancement activity than those treated liposomal vesicles. better pharmacological effect shown may be attributed bioavailability, possibly augmented higher efficiency, improved vesicle integrity afforded bile salts. Likewise, Taken together, innovative techniques hold substantial promise enhancing ethnopharmacological claims BME.